Print Get Citation Citation Disclaimer: These citations have been automatically generated based on the information we have and it may not be 100% accurate. Please consult the latest official manual style if you have any questions regarding the format accuracy. AMA Citation Lennon J, Chan A. Lennon J, & Chan A Lennon, Jack, and Alex Chan. Sex differences in ischemic stroke outcomes in patients with pulmonary hypertension. 2 Minute Medicine, 19 March 2021. McGraw-Hill, 2021. AccessCardiology. https://accesscardiology.mhmedical.com/updatesContent.aspx?gbosid=555817§ionid=254698127APA Citation Lennon J, Chan A. Lennon J, & Chan A Lennon, Jack, and Alex Chan. (2021). Sex differences in ischemic stroke outcomes in patients with pulmonary hypertension. (2021). 2 minute medicine. McGraw-Hill. https://accesscardiology.mhmedical.com/updatesContent.aspx?gbosid=555817§ionid=254698127.MLA Citation Lennon J, Chan A. Lennon J, & Chan A Lennon, Jack, and Alex Chan. "Sex differences in ischemic stroke outcomes in patients with pulmonary hypertension." 2 Minute Medicine McGraw-Hill, 2021, https://accesscardiology.mhmedical.com/updatesContent.aspx?gbosid=555817§ionid=254698127. Download citation file: RIS (Zotero) EndNote BibTex Medlars ProCite RefWorks Reference Manager Mendeley © Copyright Clip Full Chapter Figures Only Tables Only Videos Only Supplementary Content Sex differences in ischemic stroke outcomes in patients with pulmonary hypertension by Jack Lennon, Alex Chan Listen +Originally published by 2 Minute Medicine® (view original article). Reused on AccessMedicine with permission. +1. Pulmonary hypertension (PH) was associated with a 15% increase in odds of prolonged hospitalization. +2. PH was associated with a 31% decrease in odds of routine home discharge. +3. There was no association between PH and in-hospital mortality, though males had 31% higher odds of dying in the hospital compared to females. +Evidence Rating Level: 3 (Average) +Systemic and pulmonary hypertension (PH) are known to be associated with cerebrovascular disease and risk factors for stroke. However, little is known about the impact of PH on acute ischemic stroke outcomes. This study aimed to investigate the association between PH and adverse in-hospital outcomes following acute ischemic stroke, as well as potential sex differences among this sample. Admissions data for acute ischemic stroke were retrieved from the US National Inpatient Sample between October 2015 and December 2017. A total of 1,106,045 (median [IQR] age = 72 [61 to 82] years, 50.41% female) participants were included in analyses. The median length of stay was 3 days (IQR 2 to 6). The 31,830 (2.88%) participants with PH, compared to those without PH, were significantly older (median age = 80, difference 9 years) and were more likely to be female (difference 14.67%). Participants with PH were more likely to have co-occurring atrial fibrillation (difference 32.25%). Participants with PH were also more likely to receive revascularization therapies such as intravenous thrombolysis and endovascular thrombectomy. PH was not found to be associated with in-hospital mortality (OR 0.96, 95% CI 0.86 to 1.09) but it was associated with increased odds of prolonged hospitalization of greater than four days (OR 1.15, 95% CI 1.09 to 1.22). PH was also associated with decreased odds of routine discharge for both males and females (OR 0.87, 95% CI 0.81 to 0.94). Compared to younger participants, older persons with PH were less likely to be discharged routinely (p = 0.028) and men with PH were 31% more likely to die while in the hospital than their female counterparts (p = 0.024). Overall, this study found that PH was not associated with in-hospital mortality, though factors such as gender impact these outcomes. Further, PH is associated with prolonged hospitalization (>4 days) and adverse discharge status. +Click to read the study in JAHA +©2020 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.