RT Book, Section
A1 Henzlova, Milena J.
A1 Hirschfeld, Cole B.
A1 Einstein, Andrew J.
A2 Heller, Gary V.
A2 Hendel, Robert C.
SR Print(0)
ID 1190156306
T1 SPECT Myocardial Perfusion Imaging Protocols
T2 Nuclear Cardiology: Practical Applications, 4e
YR 2022
FD 2022
PB McGraw Hill LLC
PP New York, NY
SN 9781264257201
LK accesscardiology.mhmedical.com/content.aspx?aid=1190156306
RD 2024/04/16
AB KEY  POINTSSingle-photon  emission  computerized  tomographic  myocardial  perfusion  imaging  (MPI)  is  the  most  common  noninvasive  modality  used  to  evaluate  patients  with  known  or  suspected  coronary  artery  disease  (CAD)  in  the  United  States.Technetium-99m  (Tc-99m)  and  thallium-201  (Tl-201)  distribute  in  the  myocardium  in  proportion  to  regional  blood  flow;  hence,  the  presence  of  a  perfusion  defect  on  imaging  signals  abnormal  myocardial  perfusion.Protocols  involve  rest  and/or  stress  imaging,  using  physical  (e.g.,  treadmill)  or  pharmacological  (e.g.,  vasodilator  or  dobutamine)  stress  agents,  over  1  or  2  days.MPI  is  believed  to  account  for  up  to  20%  of  the  total  patient  radiation  exposure  from  medical  imaging  in  the  United  States  and  thus  efforts  to  reduce  radiation  doses  from  MPI  are  important.Advancements  in  camera  technology  and  post-processing  have  enabled  more  time-efficient  studies  with  better  image  quality  and  lower  administered  radiation  doses.A  normal  stress  study  obviates  the  need  for  subsequent  rest  imaging,  thus  guidelines  now  encourage  the  use  of  stress-first  protocols  to  reduce  radiation  exposure,  reduce  cost,  and  increase  laboratory  efficiency.