RT Book, Section A1 Khalafi, Seyed Mehdi A1 Ramireddy, Archana A1 Hendel, Robert C. A2 Heller, Gary V. A2 Hendel, Robert C. SR Print(0) ID 1190156246 T1 Exercise and Pharmacologic Stress Testing T2 Nuclear Cardiology: Practical Applications, 4e YR 2022 FD 2022 PB McGraw Hill LLC PP New York, NY SN 9781264257201 LK accesscardiology.mhmedical.com/content.aspx?aid=1190156246 RD 2024/10/10 AB KEY POINTSExercise is the preferred modality for stress testing, whenever possible.Pharmacologic stress myocardial perfusion imaging (MPI) has been well validated when compared to exercise MPI in terms of diagnostic accuracy and risk stratification.Caffeine or aminophylline should be used to reverse adverse effects associated with vasodilator pharmacologic stress.Adjunctive exercise with pharmacologic stress reduces side effects, enhances image quality, and improves the detection of myocardial ischemia.Regadenoson is the most commonly used vasodilator in pharmacologic stress testing, with outstanding clinical value, ease of administration, and reduced side effects.Beta blockers and other antianginal medications should usually be withheld prior to exercise and pharmacologic stress testing. Recent studies, however, have shown that if not feasible to hold beta blockers prior to pharmacologic MPI, testing is still possible with similar results.