RT Book, Section
A1 Ungvari, Zoltan
A1 Dai, Dao-Fu
A1 Merkely, Bela
A1 Csiszar, Anna
A2 Fuster, Valentin
A2 Narula, Jagat
A2 Vaishnava, Prashant
A2 Leon, Martin B.
A2 Callans, David J.
A2 Rumsfeld, John
A2 Poppas, Athena
SR Print(0)
ID 1191381617
T1 Cardiovascular Disease and Ageing: Cellular and Molecular Mechanisms
T2 Fuster and Hurst's The Heart, 15e
YR 2022
FD 2022
PB McGraw-Hill Education
PP New York, NY
SN 9781264257560
LK accesscardiology.mhmedical.com/content.aspx?aid=1191381617
RD 2022/07/03
AB Chapter  SummaryThis  chapter  discusses  the  pathophysiology  of  the  aging  processes  in  relation  to  the  cardiovascular  system.  Epidemiological  studies  demonstrate  that  the  impact  of  conventional  cardiovascular  risk  factors  (eg,  diabetes,  hypertension,  dyslipidemia,  lifestyle  factors,  etc.)  on  the  prevalence  of  cardiovascular  and  cerebrovascular  diseases  are  dwarfed  by  the  magnitude  of  effect  of  advanced  aging  in  relation  to  these  diseases.  Both  cell  autonomous  and  cell  nonautonomous  mechanisms  of  aging  contribute  to  the  pathogenesis  of  these  diseases,  including  age-related  oxidative  stress,  mitochondrial  dysfunction,  NAD+  depletion  and  dysregulation  of  sirtuin-regulated  pathways,  impaired  proteostasis  and  autophagy,  low-grade  sterile  inflammation,  and  cellular  senescence  (see  Fuster  and  Hurst’s  Central  Illustration).  Emerging  experimental  evidence  also  supports  the  existence  and  significance  of  diverse  secreted/circulatory  factors  derived  from  distal  organs  that  modulate  cardiac  and  vascular  aging  processes  (including  endocrine  regulation).  Emerging  understanding  of  cardiac  and  vascular  aging  processes  can  enable  the  identification  of  novel  targets  for  therapeutic  intervention  to  reverse  the  deleterious  consequences  of  cardiovascular  aging  and  to  improve  cardiovascular  and  cerebrovascular  health  in  older  adults.