RT Book, Section
A1 Alonso-Gonzalez, Rafael
A1 Massarella,  Danielle
A2 Fuster, Valentin
A2 Narula, Jagat
A2 Vaishnava, Prashant
A2 Leon, Martin B.
A2 Callans, David J.
A2 Rumsfeld, John S.
A2 Poppas, Athena
SR Print(0)
ID 1202452723
T1 Complex Cyanotic Congenital Heart Disease: The “Mixing” Lesions
T2 Fuster and Hurst's The Heart, 15e
YR 2022
FD 2022
PB McGraw-Hill Education
PP New York, NY
SN 9781264257560
LK accesscardiology.mhmedical.com/content.aspx?aid=1202452723
RD 2024/04/25
AB Chapter  SummaryThis  chapter  describes  the  anatomy,  physiology,  medical  and  surgical  therapies,  and  outcomes  of  some  of  the  congenital  heart  diseases  that  result  in  cyanosis  at  presentation.  Lesions  discussed  in  detail  include  transposition  of  the  great  arteries  (d-TGA)  as  well  as  congenitally  corrected  d-TGA,  anomalies  of  pulmonary  venous  return,  and  truncus  arteriosus  (see  Fuster  and  Hurst’s  Central  Illustration).  Each  of  these  lesions,  while  resulting  from  vastly  different  aberrations  of  embryonic  cardiac  development,  culminates  in  mixed  pulmonary  and  systemic  venous  return  to  the  heart.  Depending  on  associated  cardiac  lesions,  these  forms  of  cardiac  disease  may  be  incompatible  with  life  in  the  neonatal  period  or,  at  best,  severely  life-limiting  in  their  unrepaired  form.  Advances  in  the  field  of  cardiothoracic  surgery  have  allowed  the  immediacy  of  these  threats  to  survival  to  be  assuaged.  However,  residual  lesions  are  nearly  universal  and  determine  the  future  course  and  outcomes  over  an  individual’s  lifespan.  The  population  of  adults  born  with  cyanotic  congenital  heart  disease  is  increasing,  and  knowledge  of  the  sequelae  of  residual  lesions  is  necessary  in  order  to  anticipate  and  mitigate  complications.