RT Book, Section
A1 Arbustini, Eloisa
A1 Di Toro, Alessandro
A1 Giuliani, Lorenzo
A1 Urtis, Mario
A1 Dec, G. William
A1 Narula, Jagat
A2 Fuster, Valentin
A2 Narula, Jagat
A2 Vaishnava, Prashant
A2 Leon, Martin B.
A2 Callans, David J.
A2 Rumsfeld, John
A2 Poppas, Athena
SR Print(0)
ID 1202448218
T1 Dilated Cardiomyopathy
T2 Fuster and Hurst's The Heart, 15e
YR 2022
FD 2022
PB McGraw-Hill Education
PP New York, NY
SN 9781264257560
LK accesscardiology.mhmedical.com/content.aspx?aid=1202448218
RD 2023/12/06
AB Chapter  SummaryThis  chapter  summarizes  the  pathogenesis,  diagnosis,  and  management  of  dilated  cardiomyopathy  (DCM).  The  term  DCM  covers  a  wide  spectrum  of  heart  muscle  disease  phenotypes  characterized  by  dilatation  and  systolic  impairment  of  the  left  or  both  ventricles  unexplained  by  abnormal  loading  conditions  (such  as  hypertensive,  diabetic,  valvular,  or  congenital  heart  disease)  or  coronary  artery  disease  sufficient  to  induce  the  observed  phenotype  (see  Fuster  and  Hurst’s  Central  Illustration).  The  causes  of  DCM  are  heterogeneous;  genetic  in  up  to  50%  (familial  DCM),  autoimmune/immune-mediated  and  inflammatory  (usually  postmyocarditic),  and,  less  commonly,  cardiotoxicity  (anticancer  drugs,  alcohol  abuse,  and  cirrhosis).  DCM  is  diagnosed  by  clinical  presentation  and  morphofunctional  echocardiographic  and  magnetic  resonance  imaging.  Tissue  diagnosis  is  needed  for  inflammatory  cardiomyopathies.  The  genetic  diagnosis  is  based  on  testing  of  genes  coding  for  proteins  of  the  sarcomere,  nuclear  lamina,  intermediate  filaments,  sarcolemma,  sarcoplasmic  reticulum  and  Golgi,  desmosomes,  and  mitochondria.  Familial  DCM  is  considered  when  two  or  more  family  members  are  affected,  and  diagnosed  by  family  history,  clinical  screening  of  relatives,  and  cascade  genetic  testing.  Early  diagnosis  in  relatives  can  be  framed  in  the  context  of  nondilated  hypokinetic  cardiomyopathy  based  upon  the  recommended  major  or  minor  criteria.