RT Book, Section
A1 Via, Michael A.
A1 Mechanick, Jeffrey I.
A2 Fuster, Valentin
A2 Harrington, Robert A.
A2 Narula, Jagat
A2 Eapen, Zubin J.
SR Print(0)
ID 1191186518
T1 THE METABOLIC SYNDROME
T2 Hurst's The Heart, 14e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9780071843249
LK accesscardiology.mhmedical.com/content.aspx?aid=1191186518
RD 2024/04/19
AB SummaryThis  chapter  discusses  the  pathogenesis,  diagnosis  and  therapeutic  strategies  for  metabolic  syndrome,  which  can  generally  be  defined  as  the  coexistence  of  increased  adiposity/obesity,  hypertension,  dyslipidemia  (high  serum  triglyceride  and/or  low  serum  HDL  levels),  and/or  hyperglycemia/insulin  resistance.  Various  definitions  of  this  syndrome  specify  the  requirement  of  at  least  2-3  of  these  factors,  all  of  which  substantially  increase  the  risk  of  atherosclerotic  disease.  A  large  proportion  of  the  global  adult  population  (20-35%,  depending  on  the  definition  used)  are  thought  to  have  metabolic  syndrome.  Lifestyle,  particularly  sedentary  behaviour,  has  a  dominant  role  in  the  pathogenesis  of  this  syndrome,  but  environmental  and  biological  factors  also  contribute  (see  accompanying  Hurst's  Central  Illustration).  Therapeutic  strategies,  which  should  be  applied  early,  normally  involve  a  combination  of  lifestyle  as  well  as  pharmacological  and/or  procedural  interventions.