RT Book, Section
A1 Groarke, John D.
A1 Carabello, Blase A.
A1 O’Gara, Patrick T.
A2 Fuster, Valentin
A2 Harrington, Robert A.
A2 Narula, Jagat
A2 Eapen, Zubin J.
SR Print(0)
ID 1161731540
T1 ISCHEMIC MITRAL REGURGITATION
T2 Hurst's The Heart, 14e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9780071843249
LK accesscardiology.mhmedical.com/content.aspx?aid=1161731540
RD 2024/04/25
AB Mitral  regurgitation  (MR)  can  be  classified  into  two  major  etiologic  categories:  primary  (degenerative)  and  secondary  (functional).  Primary  MR  is  a  consequence  of  disease  affecting  the  leaflets  or  chordae  tendineae,  such  as  in  mitral  valve  (MV)  prolapse,  myxomatous  degeneration,  infective  endocarditis,  or  rheumatic  disease.  These  disease  processes  are  discussed  in  Chap.  48.  In  secondary  MR,  leaflet  structure  is  normal  and  the  valve  is  more  of  an  “innocent  bystander.”  Regurgitation  results  from  a  distortion  of  the  normal  spatial  and  functional  relationships  of  the  left  ventricle  (LV)  and  valve  apparatus,  usually  as  a  consequence  of  adverse  LV  remodeling.  The  trigger  for  LV  remodeling  can  be  ischemic  (following  myocardial  infarction  [MI])  or  nonischemic  (as  with  dilated  cardiomyopathy)  (Fig.  49–1).  This  chapter  will  focus  on  chronic  ischemic  MR  (IMR)  and  will  not  discuss  acute  severe  MR  caused  by  papillary  muscle  rupture  in  the  acute/subacute  phase  of  MI.