RT Book, Section A1 Newman, Jonathan D. A1 Maron, David J. A2 Samady, Habib A2 Fearon, William F. A2 Yeung, Alan C. A2 King III, Spencer B. SR Print(0) ID 1146606683 T1 Guideline-Directed Medical Therapy for Patients with Stable Ischemic Heart Disease T2 Interventional Cardiology, 2e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9780071820363 LK accesscardiology.mhmedical.com/content.aspx?aid=1146606683 RD 2024/04/20 AB Guideline-directed medical therapy (GDMT) is an intrinsic part of management of patients with stable ischemic heart disease (SIHD) whether or not revascularization is performed. GDMT for patients with coronary disease is synonymous with secondary prevention and consists of pharmacologic and lifestyle interventions. This chapter synthesizes the evidence base behind guideline-recommended therapies for secondary prevention. Outside of the use of aspirin, we will not discuss strategies of antiplatelet therapy for post-percutaneous coronary intervention (PCI) patients, which are reviewed elsewhere. Additionally, management of anginal symptoms is outside the scope of this chapter, and angina management in patients with SIHD will be discussed only briefly in the context of other targets for secondary prevention and risk factor modification. We will begin by reviewing the GDMT targets for risk factor modification in the 2012 SIHD guidelines.1 Following this, we will review the other medical therapies that have been shown to prevent death and myocardial infarction (MI) among patients with SIHD.