RT Book, Section A1 Artman, Michael A1 Mahony, Lynn A1 Teitel, David F. SR Print(0) ID 1140362592 T1 Cardiac Morphogenesis: Implications for Congenital Cardiovascular Diseases T2 Neonatal Cardiology, 3e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9780071834506 LK accesscardiology.mhmedical.com/content.aspx?aid=1140362592 RD 2024/03/29 AB Knowledge of the role of cardiac-specific genes and their modulating factors has increased tremendously over the last decade, although 85% of human congenital cardiovascular disease is still considered to be multifactorial in origin. Advances in the molecular biology of the developing heart have greatly contributed to our understanding of cardiac morphogenesis. Manipulation of conserved genes from a variety of model organisms has increased our understanding of how genetic factors and cellular interactions contribute to cardiac development. Transgenic mouse models have allowed time-specific tracing of cells and their role in heart formation. The problem of embryo-lethality after manipulating “cardiac-specific” genes has been overcome by inducible knockout strategies. Whole genome sequencing programs have also increased understanding of mutations in humans that lead to congenital cardiovascular disease.