RT Book, Section
A1 Khadim, Ghazanfar
A1 Butler, Javed
A1 Migrino, Raymond Q.
A2 Dieter, Robert S.
A2 Dieter, Raymond A.
A2 Dieter, Raymond A.
SR Print(0)
ID 1127164505
T1 Vulnerable Plaque and the Role of Inflammation in Arterial Disease
T2 Peripheral Arterial Disease
YR 2009
FD 2009
PB McGraw-Hill Education
PP New York, NY
SN 9780071481793
LK accesscardiology.mhmedical.com/content.aspx?aid=1127164505
RD 2024/04/25
AB Atherothrombosis  is  a  systemic  arterial  disease  of  large-  and  medium-sized  arteries  including  the  coronary,  carotid,  aorta,  and  peripheral  arteries.  The  clinical  manifestations  depend  on  the  size  of  the  vessels  and  the  regional  circulation  involved  and  include  coronary  artery  disease,  stroke,  and  peripheral  vascular  disease.  A  paradigm  shift  is  occurring  with  a  change  in  focus  from  the  assessment  and  treatment  of  luminal  narrowing  toward  greater  understanding  of  the  vascular  biology  in  the  arterial  wall  that  leads  to  plaque  vulnerability.  Recent  research  has  shown  that  inflammation  plays  a  key  role  in  the  pathogenesis  and  progression  of  atherothrombosis.  The  basic  concepts  of  evolution  of  atherothrombosis,  and  the  role  of  inflammation  leading  to  vulnerable  plaque,  will  be  discussed  here.