RT Book, Section
A1 Thanaporn, Porama K.
A1 Rockson, Stanley G.
A2 Dieter, Robert S.
A2 Dieter, Raymond A.
A2 Dieter, Raymond A.
SR Print(0)
ID 1126492507
T1 Diseases of the Lymphatic Vasculature
T2 Venous and Lymphatic Diseases
YR 2011
FD 2011
PB McGraw-Hill Medical
PP New York, NY
SN 9780071601580
LK accesscardiology.mhmedical.com/content.aspx?aid=1126492507
RD 2024/04/19
AB Disease  of  the  lymphatics  can  be  either  developmental  or  acquired.  Developmental  disorders  include  heritable  forms  of  lymphatic  pathology,  such  as  Milroy's  disease,  as  well  as  congenital  vascular  malformations,  such  as  Klippel-Trenaunay  syndrome  (Table  40-1).  Acquired  forms  of  lymphatic  disease  may  arise  from  damage  to,  or  disruption  of,  the  lymphatics  by  trauma,  infection,  neoplasms,  or  iatrogenic  causes.  These  iatrogenic  sources  of  lymphatic  vascular  insufficiency  include  trauma  induced  by  surgery  or  radiotherapy.  Heritable  forms  of  lymphedema  are  uncommon,  with  the  highest  frequency  associated  with  Klinefelter's  syndrome.1  Globally,  lymphatic  filariasis  contributes  the  greatest  share  of  the  lymphatic  disease  burden,2  but  in  the  developed  world,  where  filariasis  is  distinctly  uncommon,  most  lymphatic  pathology  arises  as  a  direct  consequence  of  the  treatment  of  malignant  melanoma  and  breast  and  pelvic  malignancies.  Lymphedema  is  a  common  complication  of  treatment  and  has  increased  as  the  number  of  cancer  survivors  has  grown.3