TY - CHAP M1 - Book, Section TI - Myocardial Blood Flow Quantitation in Clinical Practice A1 - Patel, Krishna K. A1 - Heller, Gary V. A1 - Bateman, Timothy M. A2 - Heller, Gary V. A2 - Hendel, Robert C. PY - 2022 T2 - Nuclear Cardiology: Practical Applications, 4e AB - KEY POINTSLimitations of relative perfusion imaging alone include missed “balanced ischemia,” left main coronary artery disease (CAD), microvascular disease, and in cases of pharmacologic stress inability to identify lack of induced vasodilation. Measurement of myocardial blood flow reserve (MBFR) potentially resolves those issues.A normal result of both positron emission tomography (PET) myocardial perfusion and MBFR confers a lower risk of CAD and microvascular disease and lower risk of long-term major adverse cardiac events compared to spatially-relative perfusion alone.A reduced global MBFR incrementally predicts those at a higher risk of future adverse cardiovascular events, independent of perfusion defect and left ventricular ejection fraction (LVEF) assessment.All patients with reduced MBFR should be appropriately treated medically regardless of the presence of multivessel disease, given the association with high cardiovascular risk.MBFR helps guide post-test revascularization decisions SN - PB - McGraw Hill LLC CY - New York, NY Y2 - 2024/03/29 UR - accesscardiology.mhmedical.com/content.aspx?aid=1190156488 ER -