TY - CHAP M1 - Book, Section TI - THE EVALUATION AND MANAGEMENT OF STABLE ISCHEMIC HEART DISEASE A1 - Maron, Bradley A. A1 - Gersh, Bernard J. A1 - O’Gara, Patrick T. A2 - Fuster, Valentin A2 - Harrington, Robert A. A2 - Narula, Jagat A2 - Eapen, Zubin J. PY - 2017 T2 - Hurst's The Heart, 14e AB - Stable ischemic heart disease (SIHD) is a major public health concern in most developed nations and has become a leading cause of death and disability in high- as well as low- and middle-resource countries.1 Thrombosis complicating an atherosclerotic plaque is the proximate cause of acute myocardial infarction (MI) in patients with coronary artery disease (CAD) and represents the leading cause of death for men and women worldwide.2 Globally, CAD accounts for 7.4 million deaths annually, and in the United States, it is responsible for one in seven deaths per year, which in 2013 totaled approximately 370,200 fatalities.3 Despite advancements in the identification of atherosclerotic risk factors and effective therapies for primary and secondary prevention, it is estimated that annually 660,000 Americans are hospitalized or die from an initial MI, 305,000 suffer from recurrent MI, and an additional 160,000 individuals develop a clinically silent MI.3 In these patients, the transition from a clinically stable coronary atherosclerotic substrate to an acute life-threatening event remains a focus of intense investigation spanning genetic, basic, translational, and epidemiologic avenues of scientific exploration.4 In addition, there is an imprecise temporal and biological boundary on the other end of the clinical spectrum from acute coronary syndrome (ACS) to SIHD. This chapter reviews methods for diagnosing CAD, the clinical profile of patients affected by SIHD, and predictive models for assessing risk to inform treatment. Findings from contemporary landmark clinical trials that have influenced the use of specific medical, percutaneous, surgical, and hybrid treatments will also be discussed. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesscardiology.mhmedical.com/content.aspx?aid=1161730887 ER -