TY  - CHAP
M1  - Book, Section
TI  - CORONARY INTRAVASCULAR IMAGING
A1  - Bourantas, Christos V.
A1  - Onuma, Yoshinobu
A1  - Virmani, Renu
A1  - Narula, Jagat
A1  - Serruys, Patrick W.
A2  - Fuster, Valentin
A2  - Harrington, Robert A.
A2  - Narula, Jagat
A2  - Eapen, Zubin J.
PY  - 2017
T2  - Hurst's The Heart, 14e
AB  - Intravascular  imaging  continues  to  play  a  vital  role  in  advancing  our  understanding  of  the  pathophysiology  of  coronary  artery  disease  (CAD)  and  in  the  development  of  novel  cardiovascular  drugs  and  device  therapies.1,2,3,4,5,6,7  Grayscale  intravascular  ultrasound  (IVUS)  was  introduced  more  than  25  years  ago  and  has  been  an  integral  component  of  the  clinical  decision-making  process  in  the  catheterization  laboratory.  Contemporary  percutaneous  coronary  intervention  (PCI)  techniques  mostly  derived  from  initial  IVUS  observations  showing  that  high-pressure  balloon  inflation  was  required  to  adequately  appose  metallic  stents  to  the  vessel  wall  and  prevent  thrombosis.  Intravascular  imaging  has  also  evolved  with  time.  IVUS  technologies  have  added  features  such  as  tissue  characterization  by  means  of  radiofrequency  data  analysis  to  facilitate  evaluation  of  the  atherosclerotic  plaque.  This  technique  allows  a  more  sophisticated  assessment  of  changes  in  plaque  characteristics  over  time  beyond  simplistic  measurements  of  plaque  dimensions.8  However,  the  relative  poor  image  resolution  of  IVUS  and  physical  limitations  of  sound  have  hampered  a  broader  clinical  and  research  application  of  intravascular  imaging.  The  introduction  of  infrared  light-based  imaging  technologies  such  as  optical  coherence  tomography  (OCT),  which  offers  image  resolution  10  times  greater  than  that  of  IVUS,  has  allowed  interventional  cardiologists  to  explore  the  vascular  microenvironment  for  the  first  time,  whereas  near-infrared  spectroscopy  (NIRS)  has  enabled  more  reliable  assessment  of  plaque  composition  and  detection  of  the  lipid  component.9  Other  emerging  invasive  imaging  techniques,  such  as  Raman  spectroscopy  photoacoustic  imaging,  near-infrared  fluorescence  imaging,  and  time-resolved  fluorescence  spectroscopy,  are  currently  undergoing  preclinical  evaluation;  they  are  expected  to  have  clinical  applications  in  the  near  future  and  provide  additional  information  about  plaque  morphology  and  pathophysiology  (Fig.  21–1).  These  intravascular  imaging  technologies  and  their  clinical  and  research  applications  are  discussed  in  more  detail  below.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - accesscardiology.mhmedical.com/content.aspx?aid=1161727334
ER  -