TY - CHAP M1 - Book, Section TI - Special Considerations: Small Vessel and Diffuse Disease A1 - Hermiller, James B. A1 - Russell, Evan T. A2 - Samady, Habib A2 - Fearon, William F. A2 - Yeung, Alan C. A2 - King III, Spencer B. PY - 2017 T2 - Interventional Cardiology, 2e AB - Small vessel disease and diffuse coronary artery disease represent particularly challenging subsets for treatment with transcatheter coronary interventional therapies. This pathology is associated with higher risk comorbidities, such as diabetes, and is more frequently associated with female gender and diffuse coronary involvement.1 Small and diffusely diseased vessels are frequently noncompliant, calcified, tortuous, and distal in location, making these targets more technically challenging for intervention. Consequently, a higher incidence of acute complications, including significant vessel dissection, acute vessel closure, myocardial infarction, and emergent coronary bypass grafting, has historically complicated intervention in small and diffusely diseased vessels.2,3 Along with poorer acute outcomes, these subsets are plagued by high restenosis and thrombosis rates, often necessitating repeat intervention or bypass surgery.4,5 Despite the challenges and complexities inherent to small vessel intervention, the problem is common. Between 30% and 67% of all percutaneous coronary interventions involve small vessels, depending on the definition of a small vessel.6-9 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesscardiology.mhmedical.com/content.aspx?aid=1146599789 ER -