TY - CHAP M1 - Book, Section TI - Thrombolytic Therapy A1 - McDonough, Ryan J. A1 - Tcheng, James E. A2 - Samady, Habib A2 - Fearon, William F. A2 - Yeung, Alan C. A2 - King III, Spencer B. PY - 2017 T2 - Interventional Cardiology, 2e AB - The recognition of the proximate role of coronary thrombosis secondary to plaque rupture or erosion as the underlining cause of ST-segment elevation acute myocardial infarction (AMI) opened the door to the development of pharmacologic and mechanical interventions that have saved countless lives from a disease process that previously had few options and carried a high mortality rate. Thrombolytic agents were the first to provide substantial and sustained improvements in the morbidity and mortality of AMI. Summarized in this chapter are the key trials of thrombolytic agents and adjuncts to fibrinolysis along with recommendations for their application in AMI. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesscardiology.mhmedical.com/content.aspx?aid=1146596660 ER -