TY - CHAP M1 - Book, Section TI - Gene Therapy for Peripheral Arterial Disease A1 - Guerra, Daniel R. A1 - Annex, Brian H. A2 - Dieter, Robert S. A2 - Dieter, Raymond A. A2 - Dieter, Raymond A. PY - 2009 T2 - Peripheral Arterial Disease AB - Peripheral arterial disease (PAD) caused by atherosclerotic occlusions that impair blood flow to the lower extremity is now recognized as a major health care problem. Despite the growing enthusiasm and improvements in both surgical and percutaneous techniques to improve blood flow to ischemic lower extremities in PAD,1,2 a sizeable portion of patients with PAD, and especially those with critical limb ischemia (CLI), cannot benefit from these procedures because of diffuse atherosclerotic disease, poor distal conduits, or comorbid conditions that make them poor revascularization candidates. Angiogenesis can be defined as the growth and proliferation of blood vessels from existing vascular structures, while therapeutic angiogenesis is an investigational method designed to employ the growth of new blood vessels to improve the vascular supply of ischemic tissues.3,4 The purpose of this chapter is to review the evolution of gene therapy as a method to induce therapeutic angiogenesis in patients with PAD. To that end, we will review the mechanisms of new blood vessel growth, gene therapy vectors and delivery techniques, and human clinical trials that have used this technology to date. Finally, we discuss the recent studies of novel gene therapy approaches to therapeutic angiogenesis. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesscardiology.mhmedical.com/content.aspx?aid=1127169100 ER -