TY  - CHAP
M1  - Book, Section
TI  - MICROSCOPIC POLYANGIITIS
A1  - Makol, Ashima
A1  - Warrington, Kenneth J.
A2  - Dean, Steven M.
A2  - Satiani, Bhagwan
A2  - Abraham, William T.
Y1  - 2015
N1  - 
T2  - Color Atlas and Synopsis of Vascular Diseases
AB  - A  68-year-old  woman  was  hospitalized  for  evaluation  of  progressive  dyspnea,  cough,  and  hemoptysis.  She  had  a  2-month  history  of  malaise,  anorexia,  arthralgias,  and  a  30-lb  weight  loss.  Symptoms  did  not  improve  with  outpatient  antibiotic  therapy.  Laboratory  studies  were  significant  for  profound  anemia,  elevated  erythrocyte  sedimentation  rate  (ESR),  C-reactive  protein  (CRP),  and  decreased  renal  function.  Perinuclear-pattern  antineutrophil  cytoplasmic  antibody  (p-ANCA)  and  myeloperoxidase  (MPO)  antibody  were  positive.  Urinalysis  showed  microscopic  hematuria  with  granular  and  red  blood  cell  casts.  Chest  radiograph  revealed  bilateral  alveolar  infiltrates  (Figure  79-1).  Bronchoscopy  with  bronchoalveolar  lavage  was  consistent  with  alveolar  hemorrhage,  and  transbronchial  lung  biopsy  showed  changes  of  pulmonary  capillaritis  (Figure  79-2).  An  extensive  infectious  workup  was  negative.  A  diagnosis  of  microscopic  polyangiitis  (MPA)  was  made.  The  patient  was  treated  with  high-dose  corticosteroids  and  oral  cyclophosphamide,  resulting  in  gradual  clinical  improvement.  She  was  subsequently  switched  to  azathioprine  for  maintenance  of  remission.  
SN  - 
PB  - McGraw-Hill Medical
CY  - New York, NY
Y2  - 2024/04/18
UR  - accesscardiology.mhmedical.com/content.aspx?aid=1105292393
ER  -