TY - CHAP M1 - Book, Section TI - Complex Cyanotic Congenital Heart Disease: The “Mixing” Lesions A1 - Alonso-Gonzalez, Rafael A1 - Massarella, Danielle A2 - Fuster, Valentin A2 - Narula, Jagat A2 - Vaishnava, Prashant A2 - Leon, Martin B. A2 - Callans, David J. A2 - Rumsfeld, John S. A2 - Poppas, Athena Y1 - 2022 N1 - T2 - Fuster and Hurst's The Heart, 15e AB - Chapter SummaryThis chapter describes the anatomy, physiology, medical and surgical therapies, and outcomes of some of the congenital heart diseases that result in cyanosis at presentation. Lesions discussed in detail include transposition of the great arteries (d-TGA) as well as congenitally corrected d-TGA, anomalies of pulmonary venous return, and truncus arteriosus (see Fuster and Hurst’s Central Illustration). Each of these lesions, while resulting from vastly different aberrations of embryonic cardiac development, culminates in mixed pulmonary and systemic venous return to the heart. Depending on associated cardiac lesions, these forms of cardiac disease may be incompatible with life in the neonatal period or, at best, severely life-limiting in their unrepaired form. Advances in the field of cardiothoracic surgery have allowed the immediacy of these threats to survival to be assuaged. However, residual lesions are nearly universal and determine the future course and outcomes over an individual’s lifespan. The population of adults born with cyanotic congenital heart disease is increasing, and knowledge of the sequelae of residual lesions is necessary in order to anticipate and mitigate complications. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/05 UR - accesscardiology.mhmedical.com/content.aspx?aid=1202452723 ER -