TY - CHAP M1 - Book, Section TI - Aortic Valvuloplasty A1 - Rahman, Ayaz A1 - Cribier, Alain A1 - Babaliaros, Vasilis A2 - Samady, Habib A2 - Fearon, William F. A2 - Yeung, Alan C. A2 - King III, Spencer B. Y1 - 2017 N1 - T2 - Interventional Cardiology, 2e AB - Degenerative disease of the aortic valve occurs with age. Areas of cusp flexion over time develop fibrosis and calcification, impeding valve excursion and creating obstruction to left ventricular outflow.1 The most common cause of aortic stenosis (AS) is calcification of a normal trileaflet or congenital bicuspid valve.2 Calcific AS is an active disease process characterized by lipid accumulation, inflammation, and calcification, with many similarities to atherosclerosis.3-5 The degenerative process usually occurs in the sixth decade of life and beyond, but patients with additional valve pathology (bicuspid aortic valves, rheumatic heart valvular disease, radiation valvulopathy) can present much earlier in life with deterioration of valve function and consequent symptoms.6,7 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesscardiology.mhmedical.com/content.aspx?aid=1146603376 ER -