TY  - CHAP
M1  - Book, Section
TI  - Cardiac Morphogenesis: Implications for Congenital Cardiovascular Diseases
A1  - Artman, Michael
A1  - Mahony, Lynn
A1  - Teitel, David F.
Y1  - 2017
N1  - 
T2  - Neonatal Cardiology, 3e
AB  - Knowledge  of  the  role  of  cardiac-specific  genes  and  their  modulating  factors  has  increased  tremendously  over  the  last  decade,  although  85%  of  human  congenital  cardiovascular  disease  is  still  considered  to  be  multifactorial  in  origin.  Advances  in  the  molecular  biology  of  the  developing  heart  have  greatly  contributed  to  our  understanding  of  cardiac  morphogenesis.  Manipulation  of  conserved  genes  from  a  variety  of  model  organisms  has  increased  our  understanding  of  how  genetic  factors  and  cellular  interactions  contribute  to  cardiac  development.  Transgenic  mouse  models  have  allowed  time-specific  tracing  of  cells  and  their  role  in  heart  formation.  The  problem  of  embryo-lethality  after  manipulating  “cardiac-specific”  genes  has  been  overcome  by  inducible  knockout  strategies.  Whole  genome  sequencing  programs  have  also  increased  understanding  of  mutations  in  humans  that  lead  to  congenital  cardiovascular  disease.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - accesscardiology.mhmedical.com/content.aspx?aid=1140362592
ER  -