TY - CHAP M1 - Book, Section TI - Hypercoagulability and Peripheral Arterial Disease A1 - Hassell, Kathryn L. A2 - Dieter, Robert S. A2 - Dieter, Raymond A. A2 - Dieter, Raymond A. Y1 - 2009 N1 - T2 - Peripheral Arterial Disease AB - Hemostasis is the physiologic response to bleeding that occurs when a vessel wall is disrupted and is regulated through several processes. In the arterial hemostatic system, the first response is the activation, adhesion, and aggregation of platelets. The platelet plug that forms is stabilized by the deposition of fibrin, which is generated on the surface of the platelet membrane and on nearby disrupted vessel surfaces. The extent of thrombosis is limited by endogenous anticoagulant systems and by the fibrinolytic system, which preclude the development of thrombosis beyond the site of injury.1 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/23 UR - accesscardiology.mhmedical.com/content.aspx?aid=1127165139 ER -