TY - CHAP M1 - Book, Section TI - Left Atrial Appendage Closure A1 - Fahmy, Peter A1 - Saw, Jacqueline A2 - Baliga, R. R. A2 - Lilly, Scott M. A2 - Abraham, William T. PY - 2018 T2 - Color Atlas and Synopsis of Interventional Cardiology AB - An 84 year-old woman with hypertension, chronic obstructive pulmonary disease, and chronic renal insufficiency (estimated glomerular filtration, rate 38 mL/min/1.73 m2) also has paroxysmal atrial fibrillation (AF) with a CHADS2 score of 4 and CHA2DS2-VASc score of 6. She suffered a stroke a year ago and was treated with tissue plasminogen activator. This was complicated by hemorrhagic transformation, resulting in expressive dysphagia. Given her history of intracranial hemorrhage, she was deemed to be a poor candidate for long-term oral anticoagulation (OAC) and was thus referred for endovascular left atrial appendage (LAA) closure. Under general anesthesia and transesophageal echocardiography (TEE) guidance, a 28-mm Amplatzer Cardiac Plug (ACP; St. Jude Medical, St. Paul, MN) was successfully deployed. The patient was discharged the following day with no complication and was commenced on dual antiplatelet therapy (aspirin 81 mg/d and clopidogrel 75 mg/d) for 3 months, followed by aspirin indefinitely. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/19 UR - accesscardiology.mhmedical.com/content.aspx?aid=1160207592 ER -