TY  - CHAP
M1  - Book, Section
TI  - STEM CELLS AND THE CARDIOVASCULAR SYSTEM
A1  - Sallam, Karim
A1  - Wu, Joseph C.
A2  - Fuster, Valentin
A2  - Harrington, Robert A.
A2  - Narula, Jagat
A2  - Eapen, Zubin J.
PY  - 2017
T2  - Hurst's The Heart, 14e
AB  - Stem  cell  therapy  has  attracted  considerable  interest  in  the  treatment  of  cardiovascular  disorders.  This  is  driven  by  the  observation  that  the  heart’s  regenerative  capacity  is  insufficient  to  recover  from  ischemia  or  other  cardiotoxic  insults  and  the  progressive  nature  of  tissue  ischemia  in  patients  with  coronary  artery  disease  or  peripheral  arterial  disease  (PAD).  Directed  homing  of  bone  marrow–derived  stem  cells  after  myocardial  injury  produced  functional  improvements  in  animal  studies,1,2  leading  to  the  hypothesis  that  enhancing  mobilization  of  bone  marrow  stem  cells  or  their  direct  delivery  can  result  in  clinical  improvement  in  acute  or  chronic  cardiac  injury.  Similarly,  evidence  supporting  the  incorporation  of  circulating  and  bone  marrow–derived  progenitor  cells  into  newly  formed  vasculature  in  limb  ischemia  models  supported  the  premise  that  enhanced  progenitor  cell  delivery  can  reverse  tissue  ischemia.3,4  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - accesscardiology.mhmedical.com/content.aspx?aid=1161723995
ER  -