TY - CHAP M1 - Book, Section TI - DIABETES AND CARDIOVASCULAR DISEASE A1 - Farkouh, Michael E. A1 - Rayfield, Elliot J. A1 - Fuster, Valentin A2 - Fuster, Valentin A2 - Harrington, Robert A. A2 - Narula, Jagat A2 - Eapen, Zubin J. PY - 2017 T2 - Hurst's The Heart, 14e AB - SummaryThis chapter discusses the development, prevention, and management of cardiovascular disease in patients with diabetes mellitus. The number of patients with diabetes is rapidly increasing, and the condition is a major risk factor for the development of cardiovascular disease (see accompanying Hurst’s Central Illustration). A major macrovascular complication of diabetes is coronary heart disease, the leading cause of death in patients with type 2 diabetes. Diabetes-related cardiomyopathy and heart failure is also a concern; compared with individuals who do not have diabetes, risk of heart failure is double in men and five-fold higher in women with diabetes. Additionally, in diabetic patients, stoke-related mortality is almost three-fold higher than in the nondiabetic individuals. Mechanisms of development of cardiovascular disease in patients with diabetes and insulin resistance include hyperglycemia, dyslipidemia, hypercoagulability, inflammation, endothelial dysfunction, and vascular smooth muscle cell proliferation and migration. A major focus in the management of patients with type 1 or type 2 diabetes is the prevention of cardiovascular disease. Strategies known to reduce cardiovascular events in patients with diabetes include diet and lifestyle modification, good glycemic control, effective management of dyslipidemia and hypertension, and antiplatelet therapy. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesscardiology.mhmedical.com/content.aspx?aid=1191186843 ER -