TY - CHAP M1 - Book, Section TI - RHEUMATOLOGIC DISEASES AND THE CARDIOVASCULAR SYSTEM A1 - Azizad-Pinto, Parisa A1 - Tapson, Victor F. A2 - Fuster, Valentin A2 - Harrington, Robert A. A2 - Narula, Jagat A2 - Eapen, Zubin J. PY - 2017 T2 - Hurst's The Heart, 14e AB - SummaryThis chapter discusses the cardiovascular manifestations of various rheumatological conditions, including autoimmune disorders (see accompanying Hurst’s Central Illustration) and inherited connective tissue diseases. The effects of the autoimmune disorders on the cardiovascular system may result from local or systemic mechanisms. Pericarditis, valvular disease, coronary artery disease and accelerated atherosclerosis, cardiomyopathy, and heart failure are common cardiovascular manifestations of the autoimmune rheumatological disorders, which include rheumatoid arthritis, adult-onset Still disease, systemic lupus erythematosus, antiphospholipid syndrome, dermatomyositis and polymyositis, systemic sclerosis, seronegative spondyloarthropathies, and systemic vasculitides. Notably, 40% of deaths in rheumatoid arthritis are attributable to cardiovascular disease and pericarditis occurs in up to a quarter of patients with adult-onset Still disease. However, cardiovascular involvement is particularly common in patients with systemic lupus erythematosus, with up to 70% of patients showing signs of cardiovascular disease. The inherited connective tissue diseases (including Marfan syndrome, Loeys-Dietz syndrome, Ehlers-Danos syndrome, familial thoracic aortic aneurysms and dissections, pseudoxanthoma elasticum, and osteogenesis imperfecta) are generally associated with vascular aneurysms, particularly of the aorta, and aortic dissections; some of these conditions are also associated with valvular disease. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesscardiology.mhmedical.com/content.aspx?aid=1191188183 ER -