TY - CHAP M1 - Book, Section TI - ISCHEMIC MITRAL REGURGITATION A1 - Groarke, John D. A1 - Carabello, Blase A. A1 - O’Gara, Patrick T. A2 - Fuster, Valentin A2 - Harrington, Robert A. A2 - Narula, Jagat A2 - Eapen, Zubin J. PY - 2017 T2 - Hurst's The Heart, 14e AB - Mitral regurgitation (MR) can be classified into two major etiologic categories: primary (degenerative) and secondary (functional). Primary MR is a consequence of disease affecting the leaflets or chordae tendineae, such as in mitral valve (MV) prolapse, myxomatous degeneration, infective endocarditis, or rheumatic disease. These disease processes are discussed in Chap. 48. In secondary MR, leaflet structure is normal and the valve is more of an “innocent bystander.” Regurgitation results from a distortion of the normal spatial and functional relationships of the left ventricle (LV) and valve apparatus, usually as a consequence of adverse LV remodeling. The trigger for LV remodeling can be ischemic (following myocardial infarction [MI]) or nonischemic (as with dilated cardiomyopathy) (Fig. 49–1). This chapter will focus on chronic ischemic MR (IMR) and will not discuss acute severe MR caused by papillary muscle rupture in the acute/subacute phase of MI. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/09 UR - accesscardiology.mhmedical.com/content.aspx?aid=1161731540 ER -