RT Book, Section A1 Fernandez-Jimenez, Rodrigo A1 Hoit, Brian D. A1 Walsh, Richard A. A1 Fuster, Valentin A1 Ibanez, Borja A2 Fuster, Valentin A2 Harrington, Robert A. A2 Narula, Jagat A2 Eapen, Zubin J. SR Print(0) ID 1161723424 T1 NORMAL PHYSIOLOGY oF THE CARDIOVASCULAR SYSTEM T2 Hurst's The Heart, 14e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9780071843249 LK accesscardiology.mhmedical.com/content.aspx?aid=1161723424 RD 2024/04/19 AB The principal function of the cardiovascular system is to deliver oxygen and nutrients to metabolizing tissues and remove carbon dioxide and wastes from these tissues. This is accomplished by means of two specialized circulations in series: a low-resistance pulmonary and a high-resistance systemic circulation driven by specialized muscle pumps, the right and left heart (each in turn composed of a thin-walled atrium and thicker-walled ventricle), respectively. Although cardiovascular physiology can be understood at a number of hierarchical levels, the complex interplay among the intrinsic properties of the cardiomyocytes and isolated muscle, chamber mechanics, and their modulation by variable cardiac-loading conditions and neurohormonal and renal compensatory mechanisms determines the integrated performance of the cardiovascular system. Accordingly, cardiovascular physiology will be examined at cellular, isolated muscle, and organ (isolated heart and integrated systems) levels.