RT Book, Section
A1 Hajjar, Katherine A.
A1 Ruan, Jia
A2 Kaushansky, Kenneth
A2 Levi, Marcel
SR Print(0)
ID 1148374182
T1 Fibrinolysis and Thrombolysis
T2 Williams Hematology Hemostasis and Thrombosis
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9781260117080
LK accesscardiology.mhmedical.com/content.aspx?aid=1148374182
RD 2024/04/19
AB SUMMARYImproved  understanding  of  the  molecular  mechanisms  of  fibrinolysis  has  led  to  major  advances  in  fibrinolytic  and  antifibrinolytic  therapy.  Characterization  of  the  genes  for  all  the  major  fibrinolytic  proteins  has  revealed  the  structure  of  the  relevant  serine  proteases,  their  inhibitors,  and  their  receptors.  The  development  of  genetically  engineered  animals  deficient  in  one  or  more  fibrinolytic  protein(s)  has  revealed  both  expected  and  unexpected  functions.  In  addition,  we  now  have  a  catalog  of  acquired  and  inherited  disorders  reflective  of  either  fibrinolytic  deficiency  with  thrombosis  or  fibrinolytic  excess  with  hemorrhage.  These  advances  have  led  to  development  of  more  effective  and  safer  protocols  for  both  pro-  and  antifibrinolytic  therapy  in  a  variety  of  circumstances.