RT Book, Section
A1 Hammon, John W.
A1 Hines, Michael H.
A2 Cohn, Lawrence H.
A2 Adams, David H.
SR Print(0)
ID 1144151053
T1 Extracorporeal Circulation
T2 Cardiac Surgery in the Adult, 5e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9780071844871
LK accesscardiology.mhmedical.com/content.aspx?aid=1144151053
RD 2024/04/19
AB Cardiopulmonary  bypass  (CPB)  for  support  during  cardiac  surgery  is  unique  because  blood  exposed  to  foreign,  nonendothelial  cell  surfaces  is  collected  and  continuously  recirculated  throughout  the  body.  This  contact  with  synthetic  surfaces  within  the  perfusion  circuit,  as  well  as  open  tissue  surfaces  within  the  wound,  triggers  a  defense  reaction  that  involves  at  least  five  plasma  protein  systems  and  five  types  of  circulating  blood  cells.  This  inflammatory  response  to  CPB  initiates  a  powerful  thrombotic  stimulus  and  the  production,  release,  and  circulation  of  vasoactive  and  cytotoxic  substances  that  affect  every  organ  and  tissue  within  the  body.  Because  of  this,  open-heart  surgery  (OHS)  using  CPB  is  essentially  not  possible  without  anticoagulation,  usually  with  heparin;  thus  the  inflammatory  response  to  CPB  involves  the  consequences  of  exposing  heparinized  blood  to  foreign  surfaces,  not  lined  with  endothelial  cells.