RT Book, Section A1 Lawson, Christy M. A1 Grandas, Oscar A2 Dieter, Robert S. A2 Dieter, Raymond A. A2 Dieter, Raymond A. SR Print(0) ID 1127168613 T1 Approach to the Patient with Critical Limb Ischemia of the Lower Extremities: Chronic Peripheral Arterial Disease T2 Peripheral Arterial Disease YR 2009 FD 2009 PB McGraw-Hill Education PP New York, NY SN 9780071481793 LK accesscardiology.mhmedical.com/content.aspx?aid=1127168613 RD 2024/04/24 AB Chronic ischemia of the lower extremities is extremely prevalent in Western societies and accounts for a significant amount of morbidity and mortality. Atherosclerosis, although not the only cause of chronic lower extremity ischemia, is, by far, the most common. Together with critical ischemia of the heart, brain, and abdominal organs, atherosclerotic peripheral vascular disease constitutes the leading cause of death in the United States.1 As the mean age of the population increases, the number of individuals with atherosclerotic lesions of the lower extremities also rises. Patients with peripheral arterial disease (PAD) are at significantly higher risk of death compared to healthy controls from cardiovascular morbidity and mortality, as well as at increased risk of impaired functional status.2 A basic understanding of the pathogenesis, presentation, diagnosis, and treatment of chronic peripheral vascular disease is an integral part of medical and surgical practice in the United States.