RT Book, Section A1 Hassell, Kathryn L. A2 Dieter, Robert S. A2 Dieter, Raymond A. A2 Dieter, Raymond A. SR Print(0) ID 1127165139 T1 Hypercoagulability and Peripheral Arterial Disease T2 Peripheral Arterial Disease YR 2009 FD 2009 PB McGraw-Hill Education PP New York, NY SN 9780071481793 LK accesscardiology.mhmedical.com/content.aspx?aid=1127165139 RD 2024/04/19 AB Hemostasis is the physiologic response to bleeding that occurs when a vessel wall is disrupted and is regulated through several processes. In the arterial hemostatic system, the first response is the activation, adhesion, and aggregation of platelets. The platelet plug that forms is stabilized by the deposition of fibrin, which is generated on the surface of the platelet membrane and on nearby disrupted vessel surfaces. The extent of thrombosis is limited by endogenous anticoagulant systems and by the fibrinolytic system, which preclude the development of thrombosis beyond the site of injury.1