TY - CHAP M1 - Book, Section TI - Coagulation and Hypercoagulable States A1 - Thienelt, Christiane D. A1 - Hassell, Kathryn L. A2 - Dieter, Robert S. A2 - Dieter, Raymond A. A2 - Dieter, Raymond A. PY - 2011 T2 - Venous and Lymphatic Diseases AB - Hemostasis is the physiologic response to bleeding that occurs when a vessel wall is disrupted and is regulated through several processes. The first response is the activation, adhesion, and aggregation of platelets. The platelet plug that forms is stabilized by the deposition of fibrin, which is generated on the surface of the platelet membrane and on nearby disrupted vessel surfaces. The extent of thrombosis is limited by endogenous anticoagulant systems and by the fibrinolytic system, which precludes the development of thrombosis beyond the site of injury.1 SN - PB - McGraw-Hill Medical CY - New York, NY Y2 - 2024/04/19 UR - accesscardiology.mhmedical.com/content.aspx?aid=1126489378 ER -