- Following a long asymptomatic period, presentation with heart failure or angina.
- Wide pulse pressure with associated peripheral signs.
- Diastolic decrescendo murmur at the left sternal border.
- Left ventricular dilation and hypertrophy with preserved function.
- Presentation and findings dependent on the rapidity of onset of regurgitation.
- Diagnosis confirmed and severity estimated by Doppler echocardiography, aortography, magnetic resonance imaging, or computed tomography angiography.
Normally, the integrity of the aortic orifice during diastole is maintained by an intact aortic root and firm apposition of the free margins of the three aortic valve cusps. Aortic regurgitation (AR) may therefore be caused by a variety of disorders affecting the valve cusps or the aortic root (or both) (Table 18–1). With rheumatic heart disease becoming less common, nonrheumatic causes currently account for most of the underlying causes of AR, including congenitally malformed aortic valves, infective endocarditis, and connective tissue diseases. Disorders affecting the aortic root also account for a large number of patients with AR. These conditions include cystic medial necrosis, Marfan syndrome, aortic dissection, and inflammatory diseases. Even in the absence of any obvious abnormality of the aortic valve or root, severe systemic hypertension has been reported to cause significant AR.
Table 18–1. Causes of Aortic Regurgitation |Favorite Table|Download (.pdf)
Table 18–1. Causes of Aortic Regurgitation
Aortic cusp abnormalities
Infectious: Bacterial endocarditis, rheumatic fever
Congenital: Bicuspid aortic valve, Marfan syndrome
Inflammatory: Systemic lupus erythematosus, rheumatoid arthritis, Behçet syndrome
Degenerative: Myxomatous (floppy) valve, calcific aortic valve
Diet drug valvulopathy
Aortic root abnormalities
Aortic root dilatation: Marfan syndrome, syphilis, ankylosing spondylitis, relapsing polychondritis, idiopathic aortitis, annuloaortic ectasia, cystic medial necrosis, Ehlers-Danlos syndrome
Loss of commissural support: Aortic dissection, trauma, ventricular septal defect
Supravalvular aortic stenosis
Roberts WC, et al. Causes of pure aortic regurgitation in patients having isolated aortic valve replacement at a single US tertiary hospital (1993 to 2005). Circulation.
The presentation and findings in patients with AR depend on its severity and rapidity of onset. The hemodynamic effects of acute severe AR are entirely different from the chronic type, and the two will be discussed separately.
Chronic Aortic Regurgitation
In response to the left ventricular volume overload associated with AR, progressive left ventricular dilation occurs. This results in a higher wall stress, which stimulates ventricular hypertrophy and which, in turn, tends to normalize wall stress. Patients with severe AR may have the largest end-diastolic volumes produced by any other heart disease and yet their end-diastolic pressures are not uniformly elevated. In keeping with the Frank-Starling mechanism, the stroke volume is also increased. Thus, despite the presence of regurgitation, a normal effective forward cardiac output can be maintained. This state persists for several years. Gradually, left ventricular diastolic properties and contractile function start to decline. The adaptive dilation and hypertrophy can no longer match ...