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The study of the heart and great vessels has expanded since the days of Andreas Vesalius, the great 16th-century anatomist who recognized the impact of anatomy on the practice of medicine.1 During the European Renaissance, the tomographic approach to the study of cardiac anatomy became popular because of its artistically based correlations. This is vividly depicted in the drawings of Leonardo da Vinci2 (Fig. 4–1), the first comparative anatomist since Aristotle (see Chap. 1). During the ensuing nearly 400 years, however, interest in cardiac anatomy was very sporadic and limited to a few zealous and pioneering physicians, anatomists, and artists. The 19th century ushered in the era of anatomic dissection for the study of physiologic and pathophysiologic processes. Virchow in 1885 described the inflow-outflow method of cardiac dissection, which followed the direction of blood flow.3 It was quick and simple and became the dissection method of choice. The works of Virchow and Osler paved the way to understanding the pathophysiologic basis of such diseases as pulmonary embolism, endocarditis, and heart failure.4 Renewed interest in the study of cardiac anatomy and pathology was facilitated by the rise in autopsy rates in Europe and North America during the first half of the 20th century.5 Herrick described the clinical features of coronary thrombosis.5 Later, Blumgart, Schlesinger, and Zoll advanced our understanding of coronary artery disease through elegant clinicopathologic correlations.5

Figure 4–1.
Graphic Jump Location

Four-chamber tomographic section of the heart as illustrated by Leonardo da Vinci. Note the thin-walled right ventricle and thick-walled left ventricle and detailed anatomic connections. Reproduced with permission from O'Malley and Saunders.2


These achievements notwithstanding, however, they were limited to postmortem examinations. The advent of cardiac surgery in the 1950s, followed by coronary angiography, was a major impetus for promoting the study of in vivo clinicopathologic anatomic correlations. Although cardiac surgeons were quick to appreciate the importance of having a detailed understanding of cardiac anatomy, clinical cardiologists were more interested in pathophysiology. However, with the introduction of noninvasive imaging techniques (echocardiography, CT, MRI, and single photon-emission computed tomography [SPECT]) over the past 3 decades, the perception of cardiac anatomy and pathophysiology radically changed for all of medicine in general and cardiology in particular.


With increasing use of tomographic techniques in the diagnosis and management of cardiovascular diseases, there has been a corresponding decrease in the use of autopsy for anatomic correlations. The reasons for this decrease are complex and controversial and include an increased confidence in technology, lack of reimbursement for the cost of autopsy, and rescinding the mandate for autopsies for hospital accreditation.4 Nonetheless, autopsy still uncovers unexpected processes in approximately 15% of cases and is an invaluable tool for quality assurance programs.


Today, at the beginning of the 21st century, there is a resurgence in the clinicopathologic correlative approach ...

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